Despite the general lack of regulated testing, THC-free (or of concentration less than 0.01%) CBD oil is considered generally safe and non-addictive. Despite this fact, there are a few side effects to watch out for, particularly in higher doses.
Appetite changes, weight gain and loss, and fatigue were all reported in some studies.
There are also a few contraindications for using CBD oil tinctures. Those who take medications that list a grapefruit warning risk the same adverse effects with CBD, since both affect the same metabolic markers that determine how a drug passes through your system.
Other antidepressant and antipsychotic drugs could interact with CBD oil, either resulting in toxicity or in reduced effectiveness for a drug that you need. This is why it’s important to always consult your doctor before trying a new supplement, as you never know how CBD could interact with your medical condition.
Until more testing is done, it’s best to consult your doctor and start on lower doses first.